Genesis of cancer
This programme covers the molecular aspects of cancers occurring beyond the bone marrow, blood or lymphoid tissues. This will include most relevant solid cancers such as breast, lung and liver cancer and study aspects that are relevant for all cancers but more accessible in solid cancers, such as inflammatory processes. The programme also covers the study of cancer stroma and non-cancerous diseases sharing molecular causes and physiologic aspects with cancer.
This programme covers all malignancies emerging from the lymphoid lineage and its tissues including acute lymphoblastic leukaemia, lymphoma and myeloma. For solid tissues, we will leverage the power of spatial transcriptomics to dissect the interactions of malignant cells with their microenvironment.
This programme covers acute myeloid leukaemias as well as other myeloid malignancies originating in the bone marrow such as myelodysplastic syndromes and myeloproliferative neoplasms. We will study these diseases in the context of bone marrow as a complex tissue and consider clonal evolution as an early step.
Transplantation and immunotherapy
This programme covers all aspects of haematopoietic stem cell transplantation including the immunological complications of allogenic transplants such as graft versus host disease. The programme further addresses all aspects of immunotherapy including cell-based therapies (NK, MSC, CAR-T) and immune check point inhibitors.