Myeloid neoplasms are a group of diseases in which the bone marrow produces an abnormal quantity of precursors for red blood cells, platelets or certain types of white blood cells. This leads to a variety of symptoms and from fatigue to bones fragility and, eventually, to a higher risk of developing Acute Myeloid Leukemia (AML).
Despite the advances produced during the last decades, not all those diagnosed benefit from efficient therapies. Advancing in the knowledge of myeloid neoplasms is, therefore, paramount to increase both prognosis and survival of patients.
Our research group is searching for key molecular features of myeloid neoplasms that could be used as therapeutic targets. In particular, we are focusing our efforts towards:
Myeloma and other monoclonal gammopathies
Mechanisms of progression in monoclonal gammopathies
Also, we are seeking to improve the overall knowledge of the neoplasm microenvironment, the conditions where malignant cells live and proliferate, as well as how the body defenses respond to it.