Endothelial pathobiology and microenvironment

Program

Genesis of cancer

Preclinical models

Belongs to

IJC Can Ruti

Contact

OVERVIEW

Our research is devoted to study the biology of the endothelium and its role in disease towards the development of therapeutic strategies to target this compartment. Specifically, we aim to discover the fundamental insights of vessel growth and function in developmental setting as well as to identify the pathological contexts in which the vasculature plays a critical role either intrinsically, as in vascular anomalies, or extrinsically as in cancer. 
 

OUR RESEARCH

Blood vessels are crucial components of every organ, as they maintain tissue homeostasis by ensuring: (i) transport of gases, nutrients, waste products and circulating cells, (ii) blood coagulation, and (iii) vascular tone and barrier. The endothelium lines the lumen of blood vessels and regulates the dynamic passage of materials and cells, whereas mural cells adhere to the abluminal surface of the endothelium and regulate vessel growth, permeability, and function. Both excessive and insufficient vascular network is deleterious for organisms and lead to a broad spectrum of pathologies. 
 
The overall aim of the Graupera lab is to understand the mechanisms that regulate the vasculature in development, homeostasis, and disease. Most of our research has focused on the endothelium that plays an active role in important physiological processes and diseases such congenital disorders, obesity, and cancer. 
 
Over the past decade, we have taken advantage of the PI3K pathway as a paradigm to understand how intracellular roads regulate vessel morphogenesis, and how this knowledge can be translated into therapeutic opportunities for diseases with aberrant angiogenesis. 
 
For our research, our lab develops unique animal models including, established cell lines, and patient-derived samples. We apply a holistic approach utilizing state-of-the-art techniques as high-throughput analysis, next-generation sequencing, single cell RNA sequencing, phosphor/proteomics, and high-resolution imaging. Our lab closely collaborates with clinicians to translate our research into the clinic at both the diagnostic and therapeutic levels.

 

OUR GOALS

The Graupera lab is devoted to 5 main research lines:

  1. Insights on developmental vessel growth and function. 
  2. Understanding oncoproteins-related developmental disorders.  
  3. To study tumor-stroma interaction.  
  4. Identify vascular therapies to treat metabolic disorders. 
  5. To study endothelial and hematopoietic cell interface

Video

Selected Publications

Current Grants

HR23-00090

Fundació "la caixa"

BARCODEC Applying DNA and optical barcoding to study endothelial progenitor cells in physiology and disease

21CVD01

Leducq foundation

CARDIOBAT network Brown Fat and Cardiovascular Health: Genetic Determinants and Molecular Mechanisms

21-0159

Worldwide cancer research

PERISUPPRESS Identifying properties of tumour suppressive pericytes for cancer therapy

2021 SGR 01320

Agència de gestió d'ajuts universitaris i de recerca

Patofisiologia de l'endoteli i metabolisme

IJC-21-001

Pten research foundation

Preclinical investigation of vascular malformations in PTEN hamartoma tumour syndrome

PFERO2023.01

Fundació d'estudis i recerca oncològica

Identifying angiokines that promote BCa metastatic growth in bone (kineMET)

202319 30 31

Fundació la marató de tv3

EndoTENSION Decoding the Endothelial cell intrinsic mechanisms causing portosinusoidal hyperTENSION

GCTRA18006CARR

Fundación científica de la asociación española contra el cáncer

PROSTARGET Vulnerabilities of Tumour and Stroma Interactions in Castration-Naïve Metastatic Prostate Cancer

HR22-00316

Fundació "la caixa"

AngioHeArt Understanding and promoting the growth and regenerative functions of blood vessels in heart disease

955534

European commission

PIPgen PI3K/PTEN-related monogenic disease to understand cancer.

PCI2024-153458

Ministerio de ciencia, innovación y universidades

Understanding and repairing GNAQ-mutant blood vessels

HR21-00046

Fundació "la caixa"

NUTRITHELIUM Decoding the paracrine control of metabolic fitness by endothelial nutrient signaling

PID2020-116184RB-I00

Ministerio de ciencia e innovación

PIK3CA variants in PROS: cracking the Code of pathogenesis

955951

European commission

EVOMET Deconstructing the evolution of metastasis

ERA4HEALTHCVD-122

European commission

RepairQ Understanding and repairing GNAQ-mutant blood vessels

RED2022-134397-T

Ministerio de ciencia e innovación

Systemic and cellular interactions between cancer and metabolic signaling

PRE2021-099260

Ministerio de ciencia e innovación

LAS VARIANTES DE PIK3CA IN PROS: DESCIFRANDO EL CODIGO DE PATOGENESIS

N/A

Institució catalana de recerca i estudis avançats

Icrea Senior Call 2022

101026227

European commission

PROS-VARIANT PIK3CA-Related Overgrowth Spectrum:molecular mechanisms and preclinical modelling of PIK3CA VARIANTs