These manuscripts, highlighted as the most cited and shared by the Editors and Readers, are the finding of how DNA methylation changes contribute to transdifferentiarion in acute lymphoblastic leukemia (https://www.nature.com/articles/s41375-019-0643-1) and how epigenetic inactivation of an splicing factor contributes to breast cancer (https://www.nature.com/articles/s41388-019-0936-x) from the group of Dr Manel Esteller, and the impact of genetics in immunotherapy (https://www.nature.com/articles/s41388-019-0855-x) by the lab of Dr. Montse Sanchez-Cespedes.