Cancer Science Institute of Singapore and Institute of Hematology, CAMS, Tianjin, China

The host of this seminar is Pablo Menéndez.

Dr Toshio Suda has studied haematopoietic stem cells (HSCs) and cancer HSC niches for over forty years. His past work encompasses the purification of HSCs, identification of cytokine signalling in haematopoiesis, and the characterisation of HSC niches in bone marrow (BM). Although stem cells differentiate along with a cell autonomous intrinsic programme, this process is influenced by the microenvironment of the stem cells niche. He identified the endosteal niche for HSC niche (Cell, 2004), and subsequently established the new field of oxidative stress and stem cell aging (Nature, 2004 and Nature Med, 2006). Dr. Suda has shown that niche cells regulate stem cells through direct adhesion and through the secretion of humoral niche factors such as cytokines, chemokines and extracellular matrix molecules, which together, are thought to form a functioning unit to maintain tissue homeostasis. His goal is to develop stem cell niche cancer therapy by translating his team’s findings into clinical settings, contributing to stem cell transplantation as well as treatments of haematological disorders.

IJC Auditorium + Online
Inscripció