University of Oslo and Oslo University Hospital

The host of this seminar are Constance Delwarde and María Tovar. This lecture is organised by the CarrerasLeaders programme.

Lorena Arranz's research group “Stem Cells, Ageing and Cancer” aims at providing insights into mechanisms of hematopoietic stem cell malignant transformation, including interactions of this cell with its surrounding microenvironment, and a focus on inflammation, signaling oncometabolites and various cellular components of the stem cell niche. Their goal is the identification of novel therapeutic targets of potential clinical interest for myeloid malignancies.

Dr Arranz will give an overview of her research and present their group's recent work, where they have uncovered an important role for the metabolite succinate and its membrane receptor Succinate receptor (Sucnr1) in the regulation of hematopoiesis in health and malignancy. Their work suggests that Sucnr1 signaling restricts hematopoiesis at least partially via the hematopoietic stem and progenitor cell compartment and control of S100a9. The dysregulation of Sucnr1 emerges as contributor to malignancy, accounting for SUCNR1 expression as a predictor of prognosis in acute myeloid leukemia (AML) patients and opening new potential therapeutic avenues for these patients.

IJC Auditorium + Online
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