Dual dependence on BCL2 and MCL1 in T-cell prolymphocytic leukemia
Smith VM, Lomas O, Constantine D, Palmer L, Schuh AH, Bruce D, Gonchar O, Macip S, Jayne S, Dyer MJS, Eyre TA.
Blood Adv
Treatment of relapsed refractory T-PLL with venetoclax monotherapy results in only transient and minor clinical responses.
In vitro analyses pre- and postvenetoclax indicate dual dependence on BCL2 and MCL1; combined BCL2 and MCL1 inhibition are synergistic.
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