Cambridge Stem Cell Institute, University of Cambridge. UK

The host of this seminar is Mariona Graupera.

The Alcolea Group research interests have been focused on studying the behaviour of progenitor cells in the mouse oesophagus as a model to unveil the basic rules underlying squamous epithelial cell fate. Their work in the field has revealed how this tissue is maintained under homeostatic conditions, and how these rules switch upon injury. More recently they have been able to identify how progenitor cells alter and adapt their behaviour in response to preneoplastic mutations, reflecting their remarkable cellular plasticity. Investigating the cellular and molecular mechanisms governing this dynamic behaviour and the potential implications for early cancer development will constitute the basis of my research programme. To answer these questions, the group plans to make use of a combination of in vivo lineage tracing techniques, transcriptional network analysis, as well as 3D organoid and explant culture systems.　

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