Department of Molecular Mechanisms of Disease, University of Zurich

The host of this seminar is Àlex Vaquero.

Prof. Hottiger is an internationally recognized leader in protein ADP-ribosylation, with seminal contributions to the understanding of ADP-ribosyltransferase enzymes (i.e., PARP enzymes), post-translational signaling, and their roles in genome stability, inflammation, and cancer. His work has been instrumental in establishing ADP-ribosylation as a dynamic regulatory system linking cellular stress responses to transcriptional control and innate immune signaling in cancer. He has published extensively in high-impact journals, co-organized major international conferences on ADP-ribose metabolism, and served on national and international scientific advisory boards. In parallel, he has been actively involved in translational research and biotechnology, including co-founding Dualsystems Biotech AG and the recently established Zurich Hub for Drug and Device Development (ZH3D), as well as advisory roles related to PARP inhibitor-targeted therapies.

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