25 de abril de 2025 (12:00)
''Gene Regulation in Leukemia: from Disease Predisposition to Vulnerabilities’’
Dr. Davide Seruggia
St. Anna Children’s Cancer Research Institute (CCRI) and CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. Vienna, Austria.
The host of this lecture is Gerard Martínez
This lecture is organized by the CarrerasLeaders programme.
Davide Seruggia obtained a degree in biotechnology at the University of Milano-Bicocca (Italy) in 2010, and a PhD in molecular biology at the National Center for Biotechnology (CNB-CSIC) in Madrid (Spain) in 2014. During his PhD under the supervision of Lluis Montoliu, he focused on non-coding DNA regulatory sequences of pigmentation genes and generated several mouse lines carrying deletions of selected enhancers. Analysis of these mice highlighted the relevance of noncoding elements in regulating patterns of gene expression. In 2015, he joined the laboratory of Stuart H. Orkin at Boston Children’s Hospital, where he trained in hematology, stem cell biology, and genomics. In Boston, Seruggia used genomics and genome editing to explore the role of epigenetic factors, chromatin modifiers, and transcriptional coactivators in the context of mouse embryonic stem cells, and generated a series of mouse models to study how chromatin modifiers control hematopoiesis, erythropoiesis, and the expression of globin genes. In 2019, he was promoted to instructor in pediatrics at Harvard Medical School and attracted funding from the WES Foundation and Pedals for Pediatrics. In 2020, he was awarded an ERC Starting Grant and started his independent career in 2021, when he joined St. Anna Children’s Cancer Research Institute as principal investigator and CeMM as adjunct principal investigator.
IJC Auditorium