Zanetti_2019

Samanta Romina Zanetti

Position at Josep Carreras Institute:

Postdoctoral Investigator

Contact:

+34 935 572 810Josep Carreras Leukemia Research Institute Laboratory
School of Medicine, University of Barcelona
Carrer Casanova 143, 4th floor, South Wing
Barcelona 08036. Spain

Campus Clinic-UB

Biography

Marie Curie Skolodowska Fellow GA number 795833 InTheMLLrBALL (April 2018 - March 2020) 

Assistant Researcher of the Scientific Career Member of the National Scientific and Technical Research Council of Argentina (2012-Present)

Postdoctoral Researcher in Immunology (2009-2012). National Academy of Medicine, Buenos Aires, Argentina

PhD in Biochemistry (2008). National University of the South. Argentina

Degree in Biochemistry (2001). National University of the South. Argentina

Project

My current project is focused on the development of bispecific Chimeric Antigen Receptors (CAR) that might improve CD19 CAR-T cell therapy for r/r B-ALL; and in particular MLLrB-ALL (CD19/NG2 CAR), which has an extremely poor prognosis. CARs will achieve this improvement by reducing single-Ag immune pressure and thus preventing relapse-resistance by overcoming escape mechanisms such as the loss of CD19 expression.

How to achieve long-term persistence of CAR-T cells in the host still remains a major challenge in adoptive T cell immunotherapy, so understanding the interplay between T cells, B-ALL cells and stroma is essential to improve the efficiency of this immunotherapy. T cell inhibitory molecules regulate immune function homeostasis. However, many tumoral cells overexpress their ligands to escape immune surveillance. Thus, I will address the contribution of the B-ALL microenvironment to CAR-T cell efficacy in vitro and in vivo, and study the potential leukemic microenvironment-mediated indirect mechanism of immune escape to CAR T-cells.

Follow me on Twitter at @InTheB_ALL