SENIOR LABORATORY TECHNICIAN - STEM CELL BIOLOGY, DEVELOPMENTAL LEUKEMIA AND IMMUNOTHERAPY

Reference

SLT_PM_55

Places available

1

Deadline for application

23/07/2021

Requirements

What we need

- Solid experience in mouse handling, breeding and welfare.
- Long-standing experience with immunodeficient mice.
- Experience with PDX leukemia models.
- Knowldge on hematopoiesis and leukemia.
- Team player, organization and communication skills mandatory.
- Driving license.

 

Main Responsibilities 

- Coordinate the mouse colony managing and mouse breeding of a large immunodeficient colony (including NSG and NSGS strains).
- Have large expertise in mouse handling including:

  • Administration routes such as intraperitoneal, intravenous, subcutaneous, intratibial/intrafemoral intrahepatic and oral gavage, etc.
  • Blood sampling from sub-mandibular, tail, intracardiac and retro-orbital plexus.
  • Mouse tail biopsy and genotyping.
  • Mouse bone marrow aspirates.
  • In vivo imaging techniques including bioluminescence.
  • Mouse euthanasia and tissue sampling.
  • Animal welfare supervision.

 

- Supervise the development and evolution of the experiments.
- To offer training to other researcher/technicians and give technical support to collaborators of the group.
- Implement and discuss the “standard operating procedures” of animal experimentation with the members of the group.
- Co-design experimental plan along with the researchers of the group.
- Assist in writing procedures and protocols for the Animal Ethics Experimentation Committee.
- Flow cytometry analysis skills and cell culture knowledge will be a plus.

 

What we offer

- Salary commensurate with experience.
- Temporary position.
- Full equipped lab and access to all core facilities necessary for this project.
- Young and dynamic environment.
- Collaborative project with opportunities for networking & continuous training.
- Ad hoc training for those skills that the candidate needs to acquire/improve.
- Incorporation in a multinational and highly collaborative team.
- An exciting and innovative research project.
- Working in the mixed basic and clinical research environment of the Josep Carreras Leukaemia Research Institute.

Additional Information

Research Description 

Our lab studies human pluripotent stem cells (hESCs and iPSCs) and human multipotent stem cells (hematopoietic and mesenchymal) derived from different tissue sources in order to understand the intrinsic and extrinsic factors, and developmentally conserved pathways, driving blood endothelium and mesenchymal differentiation. We are also actively involved in modeling t(4;11) MLL-AF4+ Acute Lymphoblastic Leukemia (with special interest in deciphering the cell-of-origin and cooperating oncogenic events) as well as other hematological malignances using cord blood-derived HSPCs and hESC/hiPSC-derived blood derivatives. In parallel, we are also studying the contribution of MSCs to hematological malignances and sarcomas. 

Please also visit our group webpage:  https://www.carrerasresearch.org/en/Stem_cells_mesenchymal_cancer_and_development

 

Who we are?

Our mission is to carry out research into the basic, epidemiological, preventive, clinical and translational aspects of leukaemia and other hematologic malignancies.

The vision of the Josep Carreras Leukaemia Research Institute is that research will identify new therapeutic targets and enable us to develop more precise and less aggressive treatments.  We aspire to understand the origin and development of leukaemia and other malignant haematological pathologies in order to be able to prevent them.  We will work for a future in which all leukaemias will be curable.

For further information, please, visit our webpage: http://www.carrerasresearch.org/en and the Josep Carreras non-profit organization: https://www.fcarreras.org/en

The European Commission awarded the IJC the HR Excellence seal in July 2019. The IJC continues to work to maintain its policies in line with the Charter and Code principles.

The HRS4R has the main objective of ensuring that research centers of excellence implement and respect the requirements of the European Charter for Researchers and the Code of Conduct for hiring researchers (from here on referred to as the Charter and Code) within their human resources policies.

This EC initiative aims to promote training, professional development, and mobility for all European scientists.  The IJC supports these values and principles, which will not only serve to strengthen its internal policies but will actively stimulate excellent research and firmly situate the organization as an institution with a stimulating working environment that favors the development of its scientists.

IJC is an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, national origin, disability, and other legally protected characteristics.

Place of presentation of the candidacies

How to apply 

To apply for this opportunity, please send your resume and a cover letter and (incl. the contact details of two referees) to jobs@carrerasresearch.org including the reference: SLT_PM_55. 

 

Deadline for Applications 

Please submit your application by July 23th, 2021. 

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