T cell lymphoma
Josep Carreras Leukaemia Research Institute
Ctra de Can Ruti, Camí de les Escoles s/n
08916 Badalona, Barcelona
Our research is focused on improving the understanding of the molecular mechanisms leading to T cell lymphomas appearance. We will develop our research by determining possible defective mechanisms during thymopoiesis and by developing preclinical mice models for the study of T cell lymphomas, such as angioimmunoblastic T cell lymphoma.
With this knowledge, we expect to design and validate new therapeutic treatments more specific and effective than the ones currently available, in order to improve patient’s survival and quality of life.
T cell lymphomas can be defined as a group of malignancies caused by the uncontrolled proliferation of T cells. They constitute less than 15% of all Non-Hodgkin's lymphomas and, within this group, frequency can vary enormously.
Despite all being caused by T cell defective cell growth, little is known about its specific origin. Besides, they present a wide variety of symptoms and clinical characteristics ranging from highly aggressive (fast-growing) lymphomas, to subtypes that can develop for years without endangering the patient's life (indolent); presence of enlarged spleen, liver and/or lymph nodes; eczema and skin rash appearance; age appearance and higher incidence in men than in women. As a result of this variability, it is often difficult to establish a correct diagnosis of the disease and even more difficult to design an appropriate therapy for its specific treatment.
Our line of research aims at improving our understanding of the molecular mechanisms leading to the defective behaviour of the T cells originating this type of lymphoma, to provide more specific and effective therapies to treat T cell lymphoma, improve the prognosis and quality of life of patients and, eventually, to find a cure.
Lines of research
- Characterisation of T cell lymphoma phenotype once the disease is developed, in order to find the specific T cell population inducing its appearance.
- Study thymocytes maturation processes and mature T cells response to antigens, to try to determine if lymphoma appearance can be already settled during thymopoiesis or once the T cells leave the thymus.
- Compare, using single cell sequencing technologies, the characteristics of defective thymocytes and T cells in mice models and try to find similarities in human patient’s samples and databases.
|Laura Mondragón||Group Leaderfirstname.lastname@example.org|
|Antonio Luque García||Lab Technicianemail@example.com|
|Barbara Chalhoub||PhD Studentfirstname.lastname@example.org|
|Arnau Masó Carretero||PhD Studentemail@example.com|
Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance.Cell Metab 3 Apr 2018, 27 (4) 828-842.e7.
AIF-regulated oxidative phosphorylation supports lung cancer development.Cell Res Jul 2019, 29 (7) 579-591.
GAPDH Overexpression in the T Cell Lineage Promotes Angioimmunoblastic T Cell Lymphoma through an NF-κB-Dependent Mechanism.Cancer Cell 16 Sep 2019, 36 (3) 268-287.e10.
Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.Science 5 Jan 2018, 359 (6371) 91-97. Epub 2 Nov 2017
|Project leader:||Laura Mondragón|