POSTDOCTORAL RESEARCHER - DISSECTING THE LINK BETWEEN METABOLISM AND CHROMATIN MEDIATED BY HISTONE VARIANTS
Deadline for application
- A high level of motivation and interest.
- Relevant expertise in chromatin biology or metabolism.
- Technical expertise in cell culture methods, molecular biology and biochemistry.
- Competitive CV with a track record of publications that will allow us to apply for competitive fellowships such as MSCA, EMBO and FEBS.
- PhD title.
- 3-6 years of previous experience.
- High level of collaborative and communicative skills.
- Good level of English speaking and writing skills (required). Spanish (helpful).
What we offer
- Incorporation in a multinational and highly collaborative team.
- An innovative and interdisciplinary research project.
- Mixed basic and clinical research environment of the Josep Carreras Leukaemia Research Institute.
- The international network of the Buschbeck lab.
- The stimulating environment of the Barcelona metropolitan area.
- Contract details will be negotiated and take into account the track-record of the candidate.
- Temporary position.
- Preferential start date: Anytime between July and December 2021.
The team of Marcus Buschbeck at the Josep Carreras Leukaemia Research Institute is looking for a motivated Postdoctoral Researcher to work on the main research line of the lab aiming to understand the link between chromatin architecture and metabolism provided by histone variants.
Histone variants can replace replication-coupled histones in the nucleosome and endow chromatin with unique properties (Buschbeck and Hake, 2017, NRMCB). Three macroH2A histone variants are unique in containing a linker domain and macrodomain in addition to the histone-fold. The macrodomain of macroH2A1.1 is able to bind the NAD+ derived metabolite ADP-ribose and ADP-ribosylated proteins. As a consequence macroH2A1.1 affects cell metabolism through binding NAD+-dependent effector proteins (Posavec Marjanovic, Hurtado-Bagès et al., 2017, NSMB). Furthermore, macroH2A proteins have a yet not fully understood function in regulating three-dimensional chromatin architecture (Douet et al., 2017, JCS and Kozlowski, Corujo et al., 2018, EMBO Rep.).
We part from the hypothesis that macroH2A proteins are metabolic sensors on chromatin. Preliminary data in the lab suggests that the two other macroH2A proteins have evolved to bind other, yet unknown metabolites. We are looking for a motivated postdoc who is interested to take on the challenge to identify these metabolites and to dissect the functional relevance of metabolite-histone binding for gene regulation, cell fate and chromatin architecture. The project will build on previous results and will combine biochemical and biophysical methods, in part through established collaborations. We will further use cell culture models to dissect the molecular mechanism and analyze primary samples from KO mice.
The postdoc will incorporate into a balanced team of postdocs and PhD students and interact with other lab members working on related projects. In particular, the candidate is expected to closely interact with lab members that have generated a large amount of preliminary results.
The contract will be funded by the Ministerio de Ciencia e Innovación, bajo la convocatoria Retos Investigación de Proyectos I+D+i, nº de expediente RTI2018-094005-B-I00.
Please also visit our group webpage:
Who we are?
Our mission is to carry out research into the basic, epidemiological, preventive, clinical and translational aspects of leukaemia and other hematologic malignancies.
The vision of the Josep Carreras Leukaemia Research Institute is that research will identify new therapeutic targets and enable us to develop more precise and less aggressive treatments. We aspire to understand the origin and development of leukaemia and other malignant haematological pathologies in order to be able to prevent them. We will work for a future in which all leukaemias will be curable.
The European Commission awarded the IJC the HR Excellence seal in July 2019. The IJC continues to work to maintain its policies in line with the Charter and Code principles.
The HRS4R has the main objective of ensuring that research centers of excellence implement and respect the requirements of the European Charter for Researchers and the Code of Conduct for hiring researchers (from here on referred to as the Charter and Code) within their human resources policies.
This EC initiative aims to promote training, professional development, and mobility for all European scientists. The IJC supports these values and principles, which will not only serve to strengthen its internal policies but will actively stimulate excellent research and firmly situate the organization as an institution with a stimulating working environment that favors the development of its scientists.
IJC is an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, national origin, disability, and other legally protected characteristics.
Place of presentation of the candidacies
How to apply
To apply for this opportunity, please send your resume and a cover letter (incl. the contact details of two referees) to firstname.lastname@example.org and email@example.com, including the reference REF.: PDR_MB_31.
Deadline for Applications
Please submit your application by May 16th, 2021.