Dr. Javierre & Tomás-Daza, Rovirosa

A refined method to peer into cancer cells’ inner working unlocks a hallmark of cancer: the interactome

Researchers at the Josep Carreras Leukaemia Research Institute have developed a method to analyze long-range interactions in the DNA -the interactome- from a very low amount of starting material. The method, named liCHi-C, opens the door to study the interactome of patient-derived samples instead of in vitro models for the first time and help us understand how alterations in regulatory regions affect the inner working of cancer cells.

Read more
Diego Sánchez & Néstor Tirado

Researchers from the Hospital 12 de Octubre and the Josep Carreras Institute create a cell therapy based on STAb cells for a type of leukemia with few treatment options

Researchers of the Hospital Universitario 12 de Octubre in Madrid and the Josep Carreras Leukaemia Research Institute have developed a cell therapy for a type of leukemia which currently has very few treatment options. The innovative STAb therapy has been developed thanks to funding from the Spanish Association Against Cancer (AECC).

Read more
Manel Esteller & Verónica Dávalos

Epigenetics breaks into the clinical practice of cancer

Dr. Manel Esteller and Dr. Verónica Dávalos, researchers at the Josep Carreras Leukaemia Research Institute, describe in a new article the impact of epigenetics on cancer treatment and how it has become a crucial tool to improve early detection, predict disease progression and become a target for new treatments.

Read more
Francesc Solé 2022

Gender plays a great role in the prognosis of Myelodysplastic Syndromes

An international team of researchers on Myelodysplastic Syndromes (MDS) has found that gender is an important factor in the progression of the disease with men showing a poorer prognosis mainly due to cardiovascular interactions of anemia with mild MDS and a worse and broader mutational landscape than women. The team proposes to incorporate sex and its associated distinctive features into the informed prognostic scoring system (IPSS), to better stratify MDS patients and improve personalized decision making in the clinic.

Read more
Ballestar lab 2022

Researchers find epigenetic alterations in the immune system behind severe Covid-19

Monocytes from severe covid-19 patients show an altered epigenetic status, according to results by the Epigenetic and Immune Disease group of the Josep Carreras Leukaemia Research Institute. The alterations found in these cells, key in promoting inflammation, can explain features of the aberrant immune response against Sars-Cov-2 infection, such as impaired communication with other immune cells and maturation defects. This comprehensive analysis of monocyte’s epigenetics under severe covid-19, the first of its kind, stresses the importance of these cells in modulating the immune response.

Read more