
A refined method to peer into cancer cells’ inner working unlocks a hallmark of cancer: the interactome
Researchers at the Josep Carreras Leukaemia Research Institute have developed a method to analyze long-range interactions in the DNA -the interactome- from a very low amount of starting material. The method, named liCHi-C, opens the door to study the interactome of patient-derived samples instead of in vitro models for the first time and help us understand how alterations in regulatory regions affect the inner working of cancer cells.