The 3D Chromatin Organization Group of the Josep Carreras Leukemia Research Institute led by Biola M Javierre has recently revealed, in a joint investigation, that highly connected enhancers communities act as key drivers of lineage-specific gene programs.
The researcher Manel Esteller, director of the Josep Carreras Leukaemia Research Institute has been recognized among the 500 most influential researchers in all areas of Science, according the latest edition of the Webometrics classification.
The project, funded by the Deutsche José Carreras Leukämie Stiftung and co-led by Dr. Biola M. Javierre, Leader of the 3D Chromatin Organization Group, and Prof. Björn Chapuy, from the University of Gottingen (Germany), focuses on the study of the molecular bases of diffuse large B-cell lymphoma (DLBCL).
Dr. Manel Esteller, director of the Josep Carreras Leukemia Research Institute, published today in Blood journal, the discovery of a marker that allows predicting which patient with Hodgkin's lymphoma will present the aggressive clinical course, and will therefore be a case of special risk.
In an article that was just published in Proceedings of the National Academy of Sciences (PNAS) by the group of Dr. Manel Esteller, is solved this mystery by describing that in cancer cells the protein that generates the nucleotide "Y" is epigenetically inactivated, causing small but highly aggressive tumors.
The Myelodysplastic Syndromes Group participates in an international study, published in Nature Medicine journal, that confirms for the first time that mutation of the two TP53 gene’s copies is associated with a worse prognosis in myelodysplastic syndromes, a group of blood cancers a more frequent in elderly population.
Researchers at the Josep Carreras Leukaemia Research Institute have identified a new mechanism for the regulation of the response to metabolic stress that opens the door to new therapeutic targets in the treatment of leukaemia and other malignant haemopathies.
The researcher Manel Esteller, director of the Josep Carreras Leukaemia Research Institute, and leader in Cancer Epigenetics, has been awarded the Narcís Monturiol Medal for scientific and technological merit from the Government of Catalonia.
This spin-off, called OneChain Immunotherapeutics (OCI), was founded by the Josep Carreras Leukaemia Research Institute, ICREA, and Dr. Pablo Menéndez in Barcelona in June 2020.
Francesc Solé, leader of the Myelodysplastic Syndromes group and Blanca Xicoy, leader of the Myeloid Neoplasms group, both from the Josep Carreras Leukaemia Research Institute, collaborate in an article published in Leukemia on the classification and prognosis of Secondary Myelodysplastic Syndromes.
