Endothelial pathobiology and microenvironment
Can Ruti Campus - Ctra de Can Ruti, Camí de les Escoles s/n
08916 Badalona, Barcelona
Our research is devoted to study the biology of the endothelium and its role in disease towards the development of therapeutic strategies to target this compartment. Specifically, we aim to untackel the fundamental insigths of vessel growth and function in developmental setting as well as to identify the pathological contexts in which the vasculature plays a critical role either intrinsically, as in vascular anomalies, or extrinsically as in cancer.
Blood vessels are crucial components of every organ, as they maintain tissue homeostasis by ensuring: (i) transport of gases, nutrients, waste products and circulating cells, (ii) blood coagulation, and (iii) vascular tone and barrier. The endothelium lines the lumen of blood vessels and regulates the dynamic passage of materials and cells, whereas mural cells adhere to the abluminal surface of the endothelium and regulate vessel growth, permability and function. Both excessive and insufficient vascular network is deleterious for organisms and lead to a broad spectrum of pathologies.
The overall aim of the Graupera lab is to understand the mechanisms that regulate the vasculature in development, homeostasis and disease. Most of our research has focused on the the endothelium that plays an active role in important physiological processes and diseases such congenital disorders, obesity and cancer.
Over the past decade, we have taken advantage of the PI3K pathway as a paradigm to understand how intracellular roads regulate vessel morphogenesis, and how this knowledge can be translated into therapeutic opportunities for diseases with aberrant angiogenesis.
For our research, our lab develops unique animal models including, established cell lines, and patient-derived samples. We apply a holistic approach utilising state-of-the-art techniques as high-throughput analysis, next-generation sequencing, single cell RNA sequencing, phospho/proteomics, and high-resolution imaging. Our lab closely collaborates with clinicians to translate our research into the clinic at both the diagnostic and therapeutic levels.
The Graupera lab is devoted to 5 main research lines:
1. Insights on developmental vessel growth and function.
2. Understanding oncoproteins-related developmental disorders.
3. To study tumour-stroma interaction.
4. Identify vascular therapies to treat metabolic disorders.
5. To study endothelial and hematopoietic cell interface
Image 1: Clonal expansion in endothelial tumors
2020 - EVBO Lecture Award for 21st IVBM, Seoul, Korea September 2020.
2020 - Ayudas Fundación BBVA a Equipos de Investigación Científica en Biomedicina 2019
2019 - Best female Scientist of CIBERONC
2018 - Beca Salvador de Madariaga – Estancia de movilidad de profesores e investigadores españoles en centros extranjeros.
2017 - Beca Leonardo Fundación BBVA
2013 - Successfully evaluated for the I3 program (“Ramon y Cajal” follow up program)
2008 - Reintegration Fellowship: “Ramon y Cajal” young research investigator tenure track position from the Spanish Ministry of Science and Education
2006 - Cancer Research-UK fellowship
2004 - EMBO Post-doctoral Fellowship (LTF364-2004)
|Mariona Graupera||Group Leaderemail@example.com|
|Laia Muixi||Project Managerfirstname.lastname@example.org|
|Sandra Castillo||Senior Researcheremail@example.com|
|Pilar Villacampa||Postdoctoral Investigatorfirstname.lastname@example.org|
|Ana Angulo-Urarte||Postdoctoral Investigatoremail@example.com|
|Leonor Gouveia||Postdoctoral Investigator||Lgouveia@carrerasresearch.org|
|Judith Llena||PhD Studentfirstname.lastname@example.org|
|Helena Sabata||PhD Studentemail@example.com|
|Anabel Martinez||PhD Studentfirstname.lastname@example.org|
|Odena Vilalta||PhD Studentemail@example.com|
|Pau Cerdà||PhD Studentfirstname.lastname@example.org|
|Ane Martínez||PhD Studentemail@example.com|
|Jose Ángel Dengra Chillón||PhD Studentfirstname.lastname@example.org|
Developmental and tumour angiogenesis requires the mitochondria-shaping protein Opa1Cell Metab. 2020 May 5;31(5):987-1003.e8 , .
Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractilityNat Commun. 2018 Nov 16;9(1):4826 , .
Somatic Activating Mutations in Pik3ca Cause Sporadic Venous Malformations in Mice and HumanSci Transl Med. 2016 Mar 30;8(332):332ra43 , .
The metabolic co-regulator PGC1α suppresses prostate cancer metastasisNat Cell Biol. 2016 Jun;18(6):645-656 , .
|Project leader:||Mariona Graupera|