Office 1- 5 (first floor)
Germans Trias i Pujol Research Institute (IGTP)
Can Ruti CampusCtra de Can Ruti
Camí de les Escoles s/n08916 Badalona, Barcelona, Spain
We are a group of computational biologists seeking to understand how gene expression is affected by mutations, drug treatments and environmental exposure. Our research approach involves analysing high-throughput gene expression and related data with a view to testing or proposing hypotheses about molecular mechanisms and shedding light on the interaction between environment, genotype and phenotype. We work with genomic data from public databases, as well as data generated in collaboration with labs with complementary expertise.
Regulation of gene expression is the fine-tuning of the synthesis of the functional product of genes and is one of the most fundamental processes in life. It is the process that makes different cell types have different properties and differentiates unhealthy from healthy cells. Gene expression is regulated by internal signals (the activity of other genes, mutations, etc.) and by external signals (diet, temperature, pharmacological therapies, etc.).
Since 2011, we have been studying different aspects of gene regulation, including chromatin, DNA methylation and small non-coding RNAs. We have also been looking at how different types of exposure and drug treatments affect gene expression. We have a long-standing interest in the non-coding part of the genome, specifically non-coding sequence elements that affect gene regulation.
Our current research
Our research focuses on three main areas. Firstly, we study the effect of the environment on gene expression changes that are transmitted from parents to their offspring.We want to understand how information about our exposure to different environments may be encoded in molecules - other than DNA - inside germ cells that are transmitted between generations. Transmission of non-genetic information can influence an individual’s phenotype, or disease risk. We would like to find out which molecules in the germline carry such information.
Secondly, we work on non-coding RNAs and other non-coding elements that influence gene expression. We are interested in which non-coding elements affect gene expression and how. These include distal enhancers, small non-coding RNAs and transposable elements. Most genetic variations between individuals occur within the non-coding parts of our genomes. We want to understand which of these variations influence gene expression and potentially phenotype/disease risk.
Finally, we want to understand how epigenetic drugs affect gene expression and chromatin in different genomic contexts. Epigenetic drugs currently used in the clinic include those for the treatment of patients with acute myeloid leukaemia and myelodysplastic syndrome. Our work involves analysing data from experiments on human cell lines. A more in-depth understanding of the effects of these drugs and how they work may lead to improved or more personalized medicine in the future.
Our aim is to contribute to a better understanding of gene regulation and the consequences of drug treatments and inter-individual genetic variation in gene expression. Although most of our research is based on data from animal model organisms or cell lines, we hope that, in the long term, the knowledge acquired will increase our understanding about humans.
Extensive aberrant gene expression and genome deregulation are extremely common in cancer, especially haematological forms, and treatments targeting gene regulation pathways are being used for haematological malignancies.
Last, but not least, we hope that the data we generate and the analysis methods we develop serve as useful tools for the wider research community.
2018 - present
Teaching collaborator on the Màster de bioinformàtica i bioestadística de la calidad, Open University of Catalonia/University of Barcelona
2016 IED Program I3 award
2015 Catalan Predoctoral Fellowship (AGAUR) to Eduard Casas
2015 Group favorably evaluated by the Ramon y Cajal I3 Programme
2014 Spanish National Postdoctoral Fellowship (MINECO) to Yulia Medvedeva
2014 Max Planck - Prince of Asturias Award Mobility Grant to Eduard Casas
2014 Group recognized by the Catalan Research Agency (AGAUR)
2014 EpiGeneSys Travel Fellowship to Eduard Casas
2013 Elected Associate Member of the EU Network of Excellence EpiGeneSys
2011 Spanish National Research Grant (MICINN)
2011 European Reintegration Grant - Framework Programme 7
2010 Ramon y Cajal Award to Tanya Vavouri
|Tanya Vavouri||Group Leaderfirstname.lastname@example.org|
|Enric Canut||Estudiant Investigadoremail@example.com|
Transgenerational transmission of environmental information in C. elegans.Science 21 Abr 2017, 356 (6335) 320-323.
The small RNA content of human sperm reveals pseudogene-derived piRNAs complementary to protein-coding genes.RNA Jun 2015, 21 (6) 1085-95. Epub 22 Abr 2015
Paternal diet defines offspring chromatin state and intergenerational obesity.Cell 4 Des 2014, 159 (6) 1352-64.
Assessment of kinship detection using RNA-seq databioRxiv 13 Feb 2019, On-line preprint . Epub 13 Feb 2019
La evolución de nuevos ARN que interactúan con PIWI en mamíferos
|Data de finalització:||31/05/2024|
L ARN QUE INTERACTUA CON PIWI - SU PAPEL EN LA HERENCIA EPIGENÉTICA Y EL CÁNCER
|Data de finalització:||31/12/2018|
Ayudas para incentivar la incorporación estable de doctores (IED).
|Data de finalització:||31/12/2018|