PHD STUDENT - CHROMATIN BIOLOGY

Reference

PHD_AV_50

Places available

1

Deadline for application

15/07/2021

Requirements

What we need

 - MSc in Biology, Biomedicine or similar.
- A high level of motivation and interest.
- Excellent communication and organizational skills.
- Good level of oral and written English.

 Not required but highly valued:

 - Good academic records that allow the candidate to apply for competitive PhD calls.
- English language certificate B2.
- Previous experience in cellular and molecular biology.
- Animal Manipulation Certificate.

 

What we offer

- Temporary position.
- Full time.
- The stimulating environment of the Barcelona metropolitan area.
- An exciting and innovative research project.
- Incorporation in a well-established and highly motivated team. 
- Working in the outstanding multidisciplinary research environment of the Josep Carreras Leukaemia Research Institute.

 

Main Responsibilities

 - Study the dual enzymatic role of Sirtuins in epigenetics, stress response and genome stability through a combination of biochemistry, molecular biology, genomics, proteomics and cell biology.
- Analyze the contribution of Sirtuins to Leukemia from molecular to in vivo studies.
- Characterize Sirtuins SIRT6 and SIRT7 dependent-ADPribosylation.
- Study the dual enzymatic role of Sirtuins in epigenetics, stress response and genome stability through a combination of biochemistry, molecular biology, genomics, proteomics and cell biology.
- Analyze the contribution of Sirtuins to Leukemia from molecular to in vivo studies.
- Characterize Sirtuins SIRT6 and SIRT7 dependent-ADPribosylation.

Additional Information

Research Description 

The Chromatin Biology Laboratory led by Alex Vaquero is recognized for its experience in the study of response mechanisms under stress conditions. In particular, the group's main objective is to define the role of the sirtuin family of enzymes in the regulation of genome stability and epigenetics in response to stress and their impact in cancer and aging. Although the majority of sirtuins are NAD+-dependent deacetylases, some family members also harbour a second enzymatic activity, an ADP-ribosyltransferase (ADPRT) activity. This functional duality is intriguing and is one focus of the group’s work. Sirtuins play an important role in the hematopoietic system; as they have been seen to be involved in the maintenance of hematopoietic stem cells, cell differentiation and immune response, also they are associated with the development of some types of leukemia.

 

Please also visit our group webpage:

https://www.carrerasresearch.org/en/chromatin-biology-laboratory_126406

 

Who we are?

Our mission is to carry out research into the basic, epidemiological, preventive, clinical and translational aspects of leukemia and other hematologic malignancies.

The vision of the Josep Carreras Leukaemia Research Institute is that research will identify new therapeutic targets and enable us to develop more precise and less aggressive treatments.  We aspire to understand the origin and development of leukemias and other malignant hematological pathologies in order to be able to prevent them.  We will work for a future in which all leukemias will be curable.

For further information, please, visit our webpage:http://www.carrerasresearch.org/enand the Josep Carreras nonprofit organization: https://www.fcarreras.org/en.

The European Commission awarded the IJC the HR Excellence seal in July 2019. The IJC continues to work to maintain its policies in line with the Charter and Code principles.

The HRS4R has the main objective of ensuring that research centers of excellence implement and respect the requirements of the European Charter for Researchers and the Code of Conduct for hiring researchers (from here on referred to as the Charter and Code) within their human resources policies-

This EC initiative aims to promote training, professional development, and mobility for all European scientists.  The IJC supports these values and principles, which will not only serve to strengthen its internal policies but will actively stimulate excellent research and firmly situate the organization as an institution with a stimulating working environment that favors the development of its scientists.

IJC is an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, national origin, disability, and other legally protected characteristics.

 

Place of presentation of the candidacies

How to apply 

To apply for this opportunity, please send your resume and a cover letter and (incl. the contact details of two referees) to jobs@carrerasresearch.org including the reference: PHD_AV_50. 

 

Deadline for Applications 

Please submit your application by July 15th, 2021. 

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