Velasco_2019

Talia Velasco

Position at Josep Carreras Institute:

Postdoctoral Investigator

Contact:

+34 935 572 810Josep Carreras Leukemia Research Institute Laboratory
School of Medicine, University of Barcelona
Carrer Casanova, 143. Barcelona 08036 (Spain)

Campus Clinic-UB

Biography

Postdoctoral fellow at Lund Stem Cell Center (Lund University), Lund, Sweden (2011-2017)

PhD Molecular Microbiology and Genetics (2011). University of Salamanca (USAL) ‐ Institute of Biochemist Microbiology (IMB) (CSIC-USAL), Salamanca, Spain.

MSc Molecular Microbiology and Genetics (2007), University of Salamanca, Spain.

Degree in Biology, specialty in Fundamental Biology and Biotechnology (2005). University of Salamanca, Spain

 

Brief description of my work:

Throughout my professional career I have been involved in several projects focused on studying different molecular aspects of various types of leukemia. During my PhD, I worked on the therapeutic potential of reintroducing p53 function in a model of chronic myeloid leukemia (CML). As a postdoc, I used different murine models of acute myeloid leukemia (AML) to address the influence of hypoxia signaling and HIF-1a protein on the survival and proliferation of the leukemia stem cells. My current research deals with acute lymphoblastic leukemia (ALL) from two points of view: 1) how the MLL-AF4 translocation initiates ALL in infants, paying special attention to the cell of origin and the microenvironment where this disease originates, and 2) explore the therapeutic improved potential of CD22-CAR T cells in combination with Blinatumomab for ALL patients.