2016 June 12

A study, led by Julio Castaño of the Stem Cells, Mesenchymal Cancer and Development Group at the Hospital Clínic-UB Campus shows the impact of the oncogenic fusions of MLL-AF4 and AF4-MLL on DNA repair

A study, led by Julio Castaño of the Stem Cells, Mesenchymal Cancer and Development Group at the Hospital Clínic-UB Campus shows the impact of the oncogenic fusions of MLL-AF4 and AF4-MLL on DNA repair
The postdoctoral researcher Julio Castaño, together with the Salamanca Cancer Research Centre (Dr. Norma Gutiérrez and Dr. Ana Belén Herrero), led a project entitled, Expression of MLL-AF4 or AF4-MLL fusions does not impact the efficiency of DNA damage repair.
The project studied the impact of MLL-AF4 and AF4-MLL oncogenic fusions on DNA repair by using genome editing technology (CRISPSR-Cas9 tools) to establish that such fusions are not associated with genome instability in response to cytotoxicity. The findings of the study are therefore in line with those published by St. Jude Children's Research Hospital in Memphis concerning their massive sequencing studies that show, mysteriously, that these children with acute lymphoblastic leukemia have a very stable genome.

Click and check his paper