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Research in to the basic, epidemiological, preventive, clinical and translational aspects of leukemia and other hematologic malignancies

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Recent publications

Ribera J, Morgades M, Zamora L, Montesinos P, Gómez-Seguí I, Pratcorona M, Sarrà J, Guàrdia R, Nomdedeu J, Tormo M, Martínez-Lopez J, Hernández-Rivas JM, González-Campos J, Barba P, Escoda L, Genescà E, Solé F, Millá F, Feliu E, Ribera JM

Prognostic significance of copy number alterations in adolescent and adult patients with precursor B acute lymphoblastic leukemia enrolled in PETHEMA protocols.

Cancer 20 Jul 2015, . Epub 20 Jul 2015
Some copy number alterations (CNAs) have independent prognostic significance for adults with acute lymphoblastic leukemia (ALL).
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Pantano L, Jodar M, Bak M, Ballescà JL, Tommerup N, Oliva R, Vavouri T

The small RNA content of human sperm reveals pseudogene-derived piRNAs complementary to protein-coding genes.

RNA Jun 2015, 21 (6) 1085-95. Epub 22 Apr 2015
At the end of mammalian sperm development, sperm cells expel most of their cytoplasm and dispose of the majority of their RNA. Yet, hundreds of RNA molecules remain in mature sperm. The biological significance of the vast majority of these molecules is unclear. To better understand the processes that generate sperm small RNAs and what roles they may have, we sequenced and characterized the small RNA content of sperm samples from two human fertile individuals. We detected 182 microRNAs, some of which are highly abundant. The most abundant microRNA in sperm is miR-1246 with predicted targets among sperm-specific genes. The most abundant class of small noncoding RNAs in sperm are PIWI-interacting RNAs (piRNAs). Surprisingly, we found that human sperm cells contain piRNAs processed from pseudogenes. Clusters of piRNAs from human testes contain pseudogenes transcribed in the antisense strand and processed into small RNAs. Several human protein-coding genes contain antisense predicted targets of pseudogene-derived piRNAs in the male germline and these piRNAs are still found in mature sperm. Our study provides the most extensive data set and annotation of human sperm small RNAs to date and is a resource for further functional studies on the roles of sperm small RNAs. In addition, we propose that some of the pseudogene-derived human piRNAs may regulate expression of their parent gene in the male germline.
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Nunez-Espinosa C, Garcia-Godoy MD, Ferreira I, Rios-Kristjansson JG, Rizo-Roca D, Rico LG, Rubi-Sans G, Palacio C, Torrella JR, Pages T, Ward MD, Viscor G, Petriz J

Vybrant DyeCycle Violet stain discriminates two different subsets of CD34+ cells.

Curr Stem Cell Res Ther 28 May 2015, . Epub 28 May 2015
Studies are needed to understand the role of CD34 expressing cells with regard to efficient engraftment, especially in the adjuvant treatment of cancer.
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Zamora L, Germing U, Cabezón M, Schuler E, Arnan M, Marcé S, Coll R, Pomares H, Brings C, Palomo L, Schmeneau J, Gallardo D, Millá F, Feliu E, Xicoy B

Calreticulin mutations are not present in patients with myeloproliferative chronic myelomonocytic leukemia.

Ann. Hematol. May 2015, 94 (5) 869-71. Epub 22 Nov 2014More information
Sorigué M, Xicoy B, Grifols JR, Ribera JM

[Autoimmune hemolytic anemia refractory to medical treatment after chlorine dioxide intake in a patient with idiopathic thrombocytopenic purpura].

Med Clin (Barc) 8 Apr 2015, 144 (7) 332-3. Epub 18 Jun 2014More information